Flotufolastat F-18 is an organic chemical compound used in medicine and is labeled with the radioactive isotope fluorine-18.
Systematic name
(2S)-2-[[(1S)-1-Carboxy-4-[[(1R)-1-carboxy-4-[[4-[[(5R)-5-carboxy-5-[[(2R)-2-[[(4S)-4-carboxy-4-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]butanoyl]amino]-3-[[4-[ditert-butyl(fluoranyl)silyl]benzoyl]amino]propanoyl]amino]pentyl]amino]-4-oxobutanoyl]amino]butyl]amino]-4-oxobutyl]carbamoylamino]pentanedioic acid
Trade names; preparations
Posluma
Molecular formula and structural formula of Flotufolastat F-18:
C63H9918FN12O25Si
Mr = 1470.6299 g/mol
(2S)-2-[[(1S)-1-Carboxy-4-[[(1R)-1-carboxy-4-[[4-[[(5R)-5-carboxy-5-[[(2R)-2-[[(4S)-4-carboxy-4-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]butanoyl]amino]-3-[[4-[ditert-butyl(fluoranyl)silyl]benzoyl]amino]propanoyl]amino]pentyl]amino]-4-oxobutanoyl]amino]butyl]amino]-4-oxobutyl]carbamoylamino]pentanedioic acid
SMILES: CC(C)(C)[Si](C1=CC=C(C=C1)C(=O)NC[C@H](C(=O)N[C@H](CCCCNC(=O)CCC(=O)NCCC[C@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O)NC(=O)CC[C@@H](C(=O)O)N2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O)(C(C)(C)C)[18F]
Calculated NMR spectrum (Predict Spectra via NMRDB)
1H NMR Spektrum, 13C NMR Spektrum.
Mass-related elemental composition and isotope proportions of the compound Flotufolastat F-18 - C63H9918FN12O25Si - calculated based on molecular mass.
*) The third column lists the atomic masses or isotope masses of the elements involved and - in square brackets - the natural isotope composition.
The molar mass is M = 1470.6299373 grams per mole.
The amount of substance in one kilogram of the substance is n = 0.68 mol.
The amount of substance in one gram of the substance is n = 0.001 mol.
Monoisotopic mass: 1469.6622955488 Da - related to 12C631H9918F14N1216O2528Si.
Flotufolastat F-18 is used for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA)-positive lesions in men with suspected metastatic prostate cancer and is therefore used for diagnostic imaging. The intravenously administered active ingredient binds to the prostate-specific membrane antigen PSMA (IC50 = 4.4 nM). The radioisotope 18F undergoes β+ decay and emits positrons, which are measured using PET tomography and processed into an image.
radiopharmaceutical was approved in the USA in 2023.
For detailed information on the active ingredient, see: DrugBank DB17851, NCI Thesaurus C191871.
The table below lists producers and suppliers of Flotufolastat F-18 as a commercial chemical for laboratories, research, industry and production with the corresponding contact details.
[0] - Specialist and research articles in scientific journals via PubMed: Flotufolastat.
[1] - Young-A Heo:
Flotufolastat F 18: Diagnostic First Approval.
In: Molecular Diagnosis & Therapy, 27, 631-636, (2023), DOI 10.1007/s40291-023-00665-y.
Last update: 2024-10-19
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